Projects


Individual, independently funded, projects that contribute to the goals of the Human Glycome Project are:

1) Diversity of the human glycome
Short NameDescriptionCoordinating Institution
Determining the human glycomeTo isolate and structurally characterize all glycans in the human bodyHarvard Medical School (Richard Cummings, rcummin1_at_bidmc.harvard.edu)
Determine developmental dynamics in the human glycomeUse pluripotent stem cells (healthy and diseased), differentiate into derivatives of all germ layers and correlate the glycome with state of differentiation.Hannover Medical School (Falk Buettner, Buettner.Falk_at_mh-hannover.de)

2) Inter-individual variability of the human body fluid glycome
Short NameDescriptionCoordinating Institution
Variability of the plasma glycome in health and diseaseTo study relevance of inter-individual variability of either total plasma N-glycome, or IgG glycome in 100,000 individualsGenos Glycoscience Research Laboratory (Gordan Lauc, glauc_at_genos.hr)
Total plasma and IgG glycomes, statin therapy, and ASCVD eventsTo determine predictive power of total plasma and IgG glycome for atherosclerotic cardiovascular diseaseHarvard Medical School (Samia Mora, smora_at_bwh.harvard.edu)
Longitudinal changes in the human glycomeTo profile total plasma and IgG glycomes in 2000 individuals in three different time pointsKings College London (Frances Williams, frances.williams_at_kcl.ac.uk)
Glycome and microbiome interactionsTo evaluate interactions between human glycome and microbiome at multiple levelsKings College London (Tim Spector, tim.spector_at_kcl.ac.uk)
Glycomics in The Perth Longitudinal Study of Ageing WomenUsing the glycome to stratify longevity, cardiovascular disease risk and mortality in women aged over 70 yearsEdith Cowan University (Wei Wang, wei.wang_at_ecu.edu.au)

3) Inter-individual variability of the human tissue glycome
Short NameDescriptionCoordinating Institution
Tissue-specific glycomicsTo determine the organ-specific tissue glycosylation features in health and diseaseInstitute for Glycomics, Griffith University (Daniel Kolarich, d.kolarich_at_griffith.edu.au)
Human Gut glycobiomeThe analysis of host mucins and the interplay with prebiotics and microbial cell surface polysaccharides/biofilmsUniversity of Manchester (Sabine Flitsch, Sabine.Flitsch_at_manchester.ac.uk)
Determine the glycolipidome in kidney and heartIsolate and structurally characterize kidney glyco(sphingo)lipids as a function of age and diseaseHannover Medical School (Falk Buettner, Buettner.Falk_at_mh-hannover.de)
Variability in human milk oligosaccharide (HMO) compositionTo study fixed and modifiable maternal factors that influence inter- and intraindividual variation human milk oligosaccharide compositionUC San Diego Larsson- Rosenquist Foundation Mother- Milk-Infant Center of Research Excellence (Lars Bode)

4) Functional relevance and the regulation of the human glycome
Short NameDescriptionCoordinating Institution
Genetic regulation of protein glycosylationTo identify gene network that regulate IgG and plasma protein glycosylation by performing genome wide association studiesGenos Glycoscience Research Laboratory (Gordan Lauc, glauc_at_genos.hr)
Glycomic signatures of human diseasesTo determine changes in the glycome that associate with major human diseasesLeiden University Medical Centre (Manfred Wuhrer, m.wuhrer_at_lumc.nl)
Cancer glycomicsDetermining the glycosylation signatures of human cancersInstitute for Glycomics, Griffith University (Daniel Kolarich, d.kolarich_at_griffith.edu.au)
Host glycomic signature of HIV infection Investigating the role of host glycosylation machinery in HIV persistence and immunopathogenesisThe Wistar Institute (Mohamed Abdel-Mohsen, mmohsen_at_wistar.org)
Total plasma and IgG glycomes, statin therapy, and ASCVD eventsTo determine predictive power of total plasma and IgG glycome for atherosclerotic cardiovascular diseaseHarvard Medical School (Samia Mora, smora_at_bwh.harvard.edu)
Glycomics and glycoproteomics in liver diseaseTo analyse tissue and biofluid glycans and glycopeptides as biomarkers of liver diseaseMedical University of South Carolina (Anand Mehta, mehtaa_at_musc.edu)
Urine glycomics and glycoproteomicsTo analyse tissue and biofluid glycans and glycopeptides as biomarkers of prostate diseaseMedical University of South Carolina (Richard Drake, draker_at_musc.edu)
Plasma, tissue, urine and gut bacteria glycome in cancer, neuron, and diabetesTo characterize N-glycan, O-glycan and proteoglycan in serum, urine and intestinal bacteria glycome in individualsShanghai Institute of Materia Medica, Chinese Academy of Sciences (Kan Ding, dingkan_at_simm.ac.cn)
Host glycosylation during bacterial infectionDeciphering the role of mononuclear phagocyte glycans in response to bacterial infectionInstitute of Pharmacology and Structural Biology, CNRS-Toulouse University (Yoann Rombouts, yoann.rombouts_at_ipbs.fr)
Cell specific glycomics and glycoproteomics in autoimmunity and cancerTo characterise in a tissue and cell-specific manner (immune and non-immune cells) the glycans signature and its functional relevance in cancer and autoimmunity.Institute of Molecular Pathology and Immunology of University of Porto (Salomé Pinho, salomep_at_ipatimup.pt)
Functional glycomics and glycoproteomics in cancerTo determine glycans functional modulation in cancer biology and therapy response.Institute of Molecular Pathology and Immunology of the University of Porto (Celso Reis, celsor_at_ipatimup.pt)
The uromoduline glycomeStaging uromoduline glycosylation in controls and patients suffering from urogenital infections and kidney stonesHannover Medical School (Rita Gerardy-Schahn, Gerardy-Schahn.Rita_at_mh-hannover.de)
Human milk oligosaccharide (HMO) biosynthesis and functionTo study the biosynthetic pathway as well as structure function relationship of human milk oligosaccharides for infant health and development and throughout the lifecycleUC San Diego Larsson- Rosenquist Foundation Mother- Milk-Infant Center of Research Excellence (Lars Bode)

5) Analytical methods and standards for glycoscience
Short NameDescriptionCoordinating Institution
MS methods for high-throughput glycoproteomicsTo develop and standardize analytical methods for high-throughput glycoproteomicsLeiden University Medical Centre (Manfred Wuhrer, m.wuhrer_at_lumc.nl)
Standards for glycomics and glycoproteomics To synthesize, isolate, characterize and make available glycan and glycopeptide standardsHarvard Medical School (Richard Cummings, rcummin1_at_bidmc.harvard.edu)
Standards for glycoproteomicsTo produce defined N-glycopeptides for glycoproteomics researchInstitute for Glycomics, Griffith University (Daniel Kolarich, d.kolarich_at_griffith.edu.au)
De novo sequencing of carbohydratesHyphenated MS methods for de novo sequencing of carbohydratesUniversity of Manchester (Sabine Flitsch, Sabine.Flitsch_at_manchester.ac.uk)
Bioinformatic tools for glycoscienceTo develop bioinformatic tools to generate, store, analyse and visualise glycan dataSwiss Institute for Bioinformatics (Frederique Lisacek, Frederique.Lisacek_at_sib.swiss)
UniCarb-DBCurated database for access to searchable curated spectral glycoMS libraries (http://www.unicarb-db.org) University of Gothenburg (Niclas Karlsson, niclas.karlsson_at_medkem.gu.se)
UniCarb-DRData repositories for supporting open access storage of glycan MS data from the glycocommunity based on best practice (http://unicarb-dr.biomedicine.gu.se/)University of Gothenburg (Niclas Karlsson, niclas.karlsson_at_medkem.gu.se)
The Glycosmos PortalGlyCosmos Portal is a portal site of glycoscience that aims to integrate life science dataSoka University (Kiyoko F. Aoki-Kinoshita, kkiyoko_at_soka.ac.jp)
Genetically encoded technologies for glycoscienceGenetically encoded technologies for spatio-temporal mapping of glycans and glycan binding proteins in cells and tissues in vivoUniversity of Alberta (Prof. Ratmir Derda, ratmir_at_ualberta.ca)
Molecular sensor of IgG glycosylationGeneration of simplified tools to probe antigen-specific IgG glycosylationSanquin Research/University of Amsterdam (Gestur Vidarsson, G.Vidarsson_at_sanquin.nl)
Analysis of glycosphingolipid-derived glycans by CGE-LIFTo develop tools for high-throughput glycosphingolipid analysisHannover Medical School (Falk Buettner, Buettner.Falk_at_mh-hannover.de)
Glycoengineering of cellsGlycan active enzymes as tools for glycoengineered cellsHannover Medical School (Rita Gerardy-Schahn, Gerardy-Schahn.Rita_at_mh-hannover.de)

To include your projects in projects of the Human Glycome Project, please send short description of the project to the Steering Committee of the Human Glycome Project at info@human-glycome.org